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Cancer Research Studies
Breast Cancer Treatment Trials
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Study Title:
The TAILORx Trial: Program for the Assessment of Clinical Cancer Tests (PACCT-1) Trials Assigning Individualized Options for Treatment

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Study Title:
Post Market Clinical Study to Evaluate the Safety and Performance of the Axxent TM Electronic Brachytherapy System in Women with Resected, Early Stage Breast Cancer

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Study Title:
NSABP-B-39 A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I or II Breast Cancer 


Study Title: Program for the Assessment of Clinical Cancer Tests (PACCT-1) Trials Assigning Individualized Options for Treatment: The TAILORx Trial

What is the purpose of this study?
This study is designed to determine which patients with early stage breast cancer would be more likely to benefit from chemotherapy and reduce the use of chemotherapy  in those who are unlikely to benefit from it. 

Am I a candidate for this trial? 
In order to be a candidate for this trial:

  • You must be 18 to 75 years old.
  • Your tumor was estrogen and progesterone receptor positive.
  • Your tumor was Her2/neu negative.
  • Your lymph nodes were disease free.

Why should I participate?

  • TAILORx is studying how to predict the best treatment options based on the genetic makeup of your tumor. 
  • Your treatment will be tailored to you.
  • Your treatment may be the best treatment available.

What do I need to do?

  • Ask your physician/surgeon to order a test called Oncotype DX.
  • The test will calculate a risk for recurrence score based on the genetic makeup of your tumor.
  • You must agree to be randomized to a treatment arm that may or may not use chemotherapy in combination with hormone therapy.

If you are interested in this breast cancer research study, please contact:
Kristin Sorensen, MS, RN, research nurse
sorenk@holycrosshealth.org
301.754.7961

Principle Investigator: Cheryl Aylesworth, MD, medical oncologist

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Study Title: Post Market Clinical Study to Evaluate the Safety and Performance of the Axxent TM Electronic Brachytherapy System in Women with Resected, Early Stage Breast Cancer

What is the purpose of the study?
The Axxent Electronic Brachytherapy System study is investigating the safety and effectiveness of an innovative form of radiation therapy as part of breast conserving therapy in women with resected, early stage breast cancer.

Am I a candidate for this trial?

  • Are you at least 50 years old?
  • Were you diagnosed with Ductal Carcinoma In Situ (DCIS) or Invasive Ductal Carcinoma (IDC)? 

What do I need to do?

  • You must agree to undergo a new form of radiation therapy.
  • You must agree to have two treatments per day for five consecutive days.
  • You must have follow up visits at one week, four weeks, three months and six months post treatment.
  • You must complete several brief questionnaires.

Why should I participate?

  • You may receive the best treatment available.
  • Your time and schedule commitment is significantly less than that of standard radiation therapy (days versus weeks).

If you are interested in this breast cancer research study, please contact:
Pearl Samuel, MBBS, research assistant
301.754.8437
Samuepe@holycrosshealth.org

Principal investigator: Sheela Modin, MD, radiation oncologist

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Study Title: NSABP-B-39 A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I or II Breast Cancer 

What is the purpose of the study?
The purpose of this study is to determine whether partial breast irradiation is as effective as whole breast irradiation in early stage breast cancers.

Am I a candidate for this study?

  • Are you at least 18 years old?
  • Have you been diagnosed with Ductal Carcinoma In Situ (DCIS) or Invasive Ductal Carcinoma?
  • Did you have less than three positive nodes?

What do I need to do?

  • Agree to be randomized to partial versus whole breast irradiation.
  • Give researchers permission to obtain your blood.
  • Answer questions related to your experience.
  • Adhere to a physician visit schedule and follow up by researchers.

Why should I participate?
By participating, you are helping to determine whether partial breast irradiation is as effective or better than whole breast irradiation.

If you are interested in this breast cancer research study, please contact:
Pearl Samuel, MBBS, research assistant
301.754.8437
Samuepe@holycrosshealth.org

Principal Investigator: Sheela Modin, MD, radiation oncologist
Co-Investigator: Heather Lee, MD, radiation oncologist

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